4-fluoro-N,N-dimethylbenzamide → HCID 59560128、化合物

HRID 1177205

反応式

HRID 1177205 の反応式
COC(C1C=C(OC2C=CC(S(C)(=O)=O)=CC=2)C=C2OC(C)CC=12)=O.F[C:27]1[CH:37]=[CH:36][C:30]([C:31]([N:33]([CH3:35])[CH3:34])=[O:32])=[CH:29][CH:28]=1.[C:38]([O:42][C:43]([C:45]1[CH:55]=[C:54]([OH:56])[C:48]2[CH2:49][CH:50]([CH2:52][OH:53])[O:51][C:47]=2[CH:46]=1)=[O:44])([CH3:41])([CH3:40])[CH3:39]>>[C:38]([O:42][C:43]([C:45]1[CH:55]=[C:54]([O:56][C:27]2[CH:37]=[CH:36][C:30]([C:31](=[O:32])[N:33]([CH3:35])[CH3:34])=[CH:29][CH:28]=2)[C:48]2[CH2:49][CH:50]([CH2:52][OH:53])[O:51][C:47]=2[CH:46]=1)=[O:44])([CH3:41])([CH3:39])[CH3:40]

参加物

4

反応物 3

HCID 1410774-fluoro-N,N-dimethylbenzamideHCID 25067321tert-Butyl 4-hydroxy-2-(hydroxymethyl)-2,3-dihydrobenzofuran-6-carboxylateHCID 595604376-(4-Methanesulfonyl-phenoxy)-2-methyl-2,3-dihydro-benzofuran-4-carboxylic acid methyl ester

生成物 1

HCID 59560128HCID 59560128、化合物

実験手順

The title compound was prepared in a similar manner as described for Intermediate 1f, from 4-fluoro-N,N-dimethylbenzamide (989 mg, 5.91 mmol) and 4-hydroxy-2-hydroxymethyl-2,3-dihydro-benzofuran-6-carboxylic acid tert-butyl ester (200f) (1.500 g, 5.633 mmol) to give a white solid (154 mg, 7% yield). 1H NMR (400 MHz, CDCl3) δ 7.41 (d, J=8.59 Hz, 2 H) 7.20 (d, J=16.17 Hz, 2 H) 6.96 (d, J=8.59 Hz, 2 H) 4.87-5.03 (m, 1 H) 3.77-3.87 (m, 1 H) 3.71 (br. s., 1 H) 2.99-3.13 (m, 7 H) 2.90 (dd, J=16.55, 7.20 Hz, 1 H) 1.54 (s, 9 H); LCMS for C23H27NO6 m/z 358.20 (M-tBu+H)+.

出典と根拠

ORDレコード
ord-d1cf1d704fc54ea586f24776c0b545e2
出典データセット
uspto-grants-2010_11
特許番号
US07842713B2

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