反応式
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](F)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:12][N:13]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]2[CH:32]=[C:31]([OH:33])[C:24]3[CH2:25][CH:26]([CH:28]([F:30])[F:29])[O:27][C:23]=3[CH:22]=2)=[O:20])=[N:14]1>>[CH3:12][N:13]1[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]2[CH:32]=[C:31]([O:33][C:8]3[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][CH:7]=3)[C:24]3[CH2:25][CH:26]([CH:28]([F:30])[F:29])[O:27][C:23]=3[CH:22]=2)=[O:20])=[N:14]1参加物
3
実験手順
The title compound was prepared in a similar manner as described for Example 33, from 4-fluorophenyl methyl sulfone (28.2 mg, 0.162 mmol) and 2-difluoromethyl-4-hydroxy-2,3-dihydro-benzofuran-6-carboxylic acid (1-methyl-1H-pyrazol-3-yl)-amide (223a) (50 mg, 0.160 mmol) to give a white solid (18 mg, 24% yield). 1H NMR (400 MHz, CDCl3) δ 8.57 (s, 1 H) 7.85-8.02 (m, 2 H) 7.22-7.38 (m, 2 H) 7.02-7.21 (m, 3 H) 6.77 (d, J=2.02 Hz, 1 H) 5.94 (t, 1 H) 5.02 (br. s., 1 H) 3.78 (s, 3 H) 3.55-3.65 (m, 1 H) 3.23-3.33 (m, 1 H) 3.09 (s, 3 H); LCMS for C21H19F2N3O5S m/z 464.00 (M+H)+.
出典と根拠
- ORDレコード
- ord-960600c803bd48fc8860a49882ad046c
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07842713B2
関連ノート
読み込み中…