3-azetidinecarboxylic Acid → 1-(4-(5-(1-Phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid
反応式
[C:1]1([C:7]2([C:10]3[N:15]=[C:14]4[S:16][C:17]([C:19]5[CH:26]=[CH:25][C:22]([CH:23]=O)=[CH:21][CH:20]=5)=[N:18][C:13]4=[CH:12][CH:11]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:27]1[CH2:30][CH:29]([C:31]([OH:33])=[O:32])[CH2:28]1>>[C:1]1([C:7]2([C:10]3[N:15]=[C:14]4[S:16][C:17]([C:19]5[CH:20]=[CH:21][C:22]([CH2:23][N:27]6[CH2:30][CH:29]([C:31]([OH:33])=[O:32])[CH2:28]6)=[CH:25][CH:26]=5)=[N:18][C:13]4=[CH:12][CH:11]=3)[CH2:8][CH2:9]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
3
実験手順
Reaction of 4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (38.9 mg, 0.109 mmol) and azetidine-3-carboxylic acid (55 mg, 0.546 mmol) according to Reference R and the general procedure for reductive amination to give 1-(4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzyl)azetidine-3-carboxylic acid as a white solid. MS (ESI) m/z: Calculated: 441.2; Observed: 442.1 (M++1).
出典と根拠
- ORDレコード
- ord-1927a820dd2a42ec8205774528961b1a
- 出典データセット
- uspto-grants-2010_11
- 特許番号
- US07842685B2
反応ノート
読み込み中…