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Ethyl 4-bromobutyrate → 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-bromobutyrate | HCID 76300 | — |
| 反応物 | 3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine | HCID 57403052 | — |
| 生成物 | 1-(3-Fluoro-4-(5-(1-phenylcyclopropyl)[1,3]thiazolo[5,4-b]pyridin-2-yl)phenyl)-2-pyrrolidinone | HCID 59174902 | — |
反応手順
3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzenamine (110 mg, 0.304 mmol) was dissolved in ethyl 4-bromobutanoate (59 mg, 0.304 mmol) before it was placed in the microwave for 60 min at 140° C. The title compound was obtained after flash chromatography. MS (ESI) m/z: Calculated: 429.1; Observed: 430.1 (M++1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07842685B2 |
| 出典データセット | uspto-grants-2010_11 |
| ORD ID | ord-42bc22b3b49a4a5fa5aa4de3a2b1a162 |
| 出典メモ | uspto-grants-2010_11 |