Hydrochloric Acid → 1-(2-Trifluoromethylbenzoyl)piperazine hydrochloride

HRID 1177866

反応式

HRID 1177866 の反応式
[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:18])([F:17])[F:16])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[ClH:19]>>[ClH:19].[N:1]1([C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]([F:17])([F:16])[F:18])=[O:8])[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 167337841-[2-(Trifluoromethyl)benzoyl]piperazine

生成物 1

HCID 167337831-(2-Trifluoromethylbenzoyl)piperazine hydrochloride収率 91%

反応条件

温度
0 °C

実験手順

Ethereal HCl (30 mL) was added to piperazin-1-yl-(2-trifluoromethyl-phenyl)-methanone (5.5 g, 21.40 mmol) and the resulting mixture was stirred at 0° C. for 30 minutes. The ether was then evaporated to afford 5.7 g (91% yield) of piperazin-1-yl-(2-trifluoromethyl-phenyl)-methanone hydrochloride.

後処理

  1. customThe ether was then evaporated

出典と根拠

ORDレコード
ord-c33fd48809b94a23b094906311021c33
出典データセット
uspto-grants-2010_11
特許番号
US07842696B2

関連ノート

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