関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | Methyl 4-fluorobenzoate | HCID 67878 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Methyl 4-(4-methylpiperazin-1-yl)benzoate | HCID 1472668 | 165.4% |
反応手順
A mixture of 1-methyl-piperazine (1.3 g, 1.2 mmol) and 4-fluoro benzoic acid methyl ester (500 mg, 0.32 mmol) was stirred with heating at 120° C. for 20 hrs. Cold water then added, filtered the solid precipitated to afford 124 mg (16.4% yield) of 4-(4-methyl-piperazin-1-yl)-benzoic acid methyl ester. 1H NMR (CDCl3): δ 8.0 (d, 2H), 6.9 (d, 2H), 3.9 (s, 3H), 3.4 (t, 4H), 2.6 (t, 4H), 2.4 (s, 3H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07842696B2 |
|---|
| 出典データセット | uspto-grants-2010_11 |
|---|
| ORD ID | ord-6763c9f137b84040ac0a714402222c3c |
|---|
| 出典メモ | uspto-grants-2010_11 |
|---|
