Hydrochloric Acid → 2-Amino-1-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-ethanone hydrochloride
反応式
[ClH:1].C(OC(=O)[NH:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:28])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=2[Br:27])[CH2:14][CH2:13]1)=[O:11])(C)(C)C>O1CCOCC1>[ClH:1].[NH2:8][CH2:9][C:10]([N:12]1[CH2:17][CH2:16][N:15]([C:18](=[O:28])[C:19]2[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=2[Br:27])[CH2:14][CH2:13]1)=[O:11]参加物
4
実験手順
Saturated HCl in 1,4-dioxane (1.0 ml) was added to a stirred solution of {2-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester (375 mg, 0.82 mmol) in 1,4-dioxane (1.0 mL) at room temperature and the resulting mixture was stirred for 15 minutes. The mixture was then concentrated and the product obtained was washed with diethyl ether to afford 2-amino-1-[4-(2-bromo-5-methoxy-benzoyl)-piperazin-1-yl]-ethanone hydrochloride in 87.8% yield. LC-MS purity: 83.28%