Potassium Carbonate → 2-(1,4,7,10,13-Pentaoxa-16-azacyclooctadecan-16-yl)ethyl benzoate

HRID 1178183

反応式

[CH2:1]1[NH:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][O:6][CH2:5][CH2:4][O:3][CH2:2]1.[C:19]([O:27][CH2:28][CH2:29]Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:19]([O:27][CH2:28][CH2:29][N:18]1[CH2:1][CH2:2][O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

反応条件

温度: 80 °C

実験手順

A mixture of 26.3 g of 1-aza-18-crown-6, 19.9 g of 2-chloroethyl benzoate, 21.0 g of potassium carbonate, and 60 g of N,N-dimethylformamide was stirred for 10 hours at 80° C. The reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography. There was obtained 320 g of 2-(1,4,7,10,13-pentaoxa-16-azacyclo-octadecan-16-yl)ethyl benzoate (yield 75%).

後処理

customThe reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography

出典と根拠

ORDレコード: ord-b4693368965a4bfe9517c4f333076d06
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07276324B2

反応式

参加物

反応物 3

生成物 1

試薬・触媒・溶媒 1

反応条件

実験手順

後処理

出典と根拠

関連ノート