2,4-Diamino-6-ethoxypyrimidine → 6-Ethoxy-5-nitrosopyrimidine-2,4-diamine

HRID 1178218ノート

反応式

HRID 1178218 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][CH3:10])[CH:5]=[C:4]([NH2:11])[N:3]=1.[N:12]([O-])=[O:13].[Na+]>C(O)(=O)C.O>[N:12]([C:5]1[C:6]([O:8][CH2:9][CH3:10])=[N:7][C:2]([NH2:1])=[N:3][C:4]=1[NH2:11])=[O:13]

参加物

5

反応物 2

HCID 2226632,4-Diamino-6-ethoxypyrimidineHCID 23668193Sodium Nitrite

生成物 1

HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamine収率 68.3%

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To a solution of the compound of example 54 (6.13 g, 39.8 mmoles) in 20% aqueous acetic acid (57 ml) was added dropwise a solution of NaNO2 (3.29 g) in water (13 ml) at 80° C. A pink precipitate was formed which was stirred at 80° C. for an additional 2 hours. The reaction mixture was cooled down in the refrigerator overnight and the resulting precipitate was filtered off, yielding the title compound as a pink powder (4.98 g, yield 68%). Spectral data are identical with those described e.g. by W. Pfleiderer et al. in Chem. Ber. (1961) 94, 12.

後処理

  1. customA pink precipitate was formed which
  2. temperatureThe reaction mixture was cooled down in the refrigerator overnight
  3. filtrationthe resulting precipitate was filtered off

出典と根拠

ORDレコード
ord-b51ac65faca143009dc86180aea0013a
出典データセット
uspto-grants-2007_10
特許番号
US07276506B2

反応ノート

読み込み中…