Sodium Dithionite → 6-Ethoxypyrimidine-2,4,5-triamine

HRID 1178219ノート

反応式

HRID 1178219 の反応式
[N:1]([C:3]1[C:4]([O:11][CH2:12][CH3:13])=[N:5][C:6]([NH2:10])=[N:7][C:8]=1[NH2:9])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:10][C:6]1[N:5]=[C:4]([O:11][CH2:12][CH3:13])[C:3]([NH2:1])=[C:8]([NH2:9])[N:7]=1

参加物

4

反応物 2

HCID 24489Sodium Dithionite2 回HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamine

生成物 1

HCID 135414226-Ethoxypyrimidine-2,4,5-triamine収率 61.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

To a suspension of the compound of example 56 (7.12 g, 38.9 mmoles) in water (150 ml) at 60° C. was added sodium dithionite (46.7 mmol, 8.12 g). Additional sodium dithionite was added till the pink colour completely disappeared and a yellow solution was formed. The solution was stirred at 60° C. for another 4 hours. Water was evaporated and the resulting residue was precipitated from a small amount of water, providing the title compound as a yellow powder (4.02 g, yield 61%). Spectral data are identical with literature data (W. Pfleiderer et al. cited supra).

後処理

  1. customa yellow solution was formed
  2. customWater was evaporated
  3. customthe resulting residue was precipitated from a small amount of water

出典と根拠

ORDレコード
ord-7a1697465ee144b1a95c620d604bc5ff
出典データセット
uspto-grants-2007_10
特許番号
US07276506B2

反応ノート

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