Hydrochloric Acid → 3-Amino-3,4-dihydro-1,5-naphthyridin-2(1h)-one dihydrochloride

HRID 1178447ノート

反応式

HRID 1178447 の反応式
[Cl:1]C1SC2[NH:6][C:7]([C:9]([NH:11][CH:12]3[CH2:21][C:20]4[C:15](=CC=CC=4)[N:14](CCOC)[C:13]3=O)=[O:10])=[CH:8]C=2C=1.[ClH:28]>C(Cl)Cl.O1CCOCC1>[ClH:1].[ClH:28].[NH2:6][CH:7]1[CH2:8][C:13]2[C:12](=[CH:21][CH:20]=[CH:15][N:14]=2)[NH:11][C:9]1=[O:10]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 102506062-Chloro-N-{1-[2-(methoxy)ethyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide

生成物 1

HCID 219068583-Amino-3,4-dihydro-1,5-naphthyridin-2(1h)-one dihydrochloride

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

tert-Butyl (2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridine-3-yl)carbamate (Method 26, 263 mg, 1 mmol) was dissolved in DCM (10 mL) and treated with 4M HCl in dioxan (10 mL). After stirring at ambient temperature for 30 mins. the reaction mixture was evaporated under reduced pressure and the residue triturated with ether (20 mL), to give a white solid which was collected by filtration, washed with ether and dried. (234 mg, 100%).

後処理

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customthe residue triturated with ether (20 mL)
  3. customto give a white solid which
  4. filtrationwas collected by filtration
  5. washwashed with ether
  6. customdried

出典と根拠

ORDレコード
ord-f143c4c28ca54a0dba4b9dc85fe9bcc9
出典データセット
uspto-grants-2007_10
特許番号
US07276517B2

反応ノート

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