Acetate → 4-[6-(6-Bromo-2-methyl-pyridin-3-ylamino)-5-methoxy-pyrimidin-4-yloxy]-piperidine-1-carboxylic acid isopropyl ester

HRID 117850

反応式

[Br:23][c:24]1[cH:25][cH:26][c:27]([NH2:31])[c:28]([CH3:30])[n:29]1.[C:32]([P:33]([C:34]([CH3:35])([CH3:36])[CH3:37])[c:38]1[cH:39][cH:40][cH:41][cH:42][c:43]1-[c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)([CH3:50])([CH3:51])[CH3:52].[C:59]([O-:60])(=[O:61])[CH3:62].[C:64]([O-:65])(=[O:66])[CH3:67].[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([O:13][c:14]2[n:15][cH:16][n:17][c:18]([Cl:22])[c:19]2[O:20][CH3:21])[CH2:11][CH2:12]1.[O:53]1[CH2:54][CH2:55][O:56][CH2:57][CH2:58]1.[Pd+2:63]>>[CH:1]([CH3:2])([CH3:3])[O:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][CH:10]([O:13][c:14]2[n:15][cH:16][n:17][c:18]([NH:31][c:27]3[cH:26][cH:25][c:24]([Br:23])[n:29][c:28]3[CH3:30])[c:19]2[O:20][CH3:21])[CH2:11][CH2:12]1