(3-Methoxy-2-propylbenzyl)-dimethylamine → 3-Dimethylaminomethyl-2-propylphenol hydrobromide
反応式
C[O:2][C:3]1[C:4]([CH2:13][CH2:14][CH3:15])=[C:5]([CH:10]=[CH:11][CH:12]=1)[CH2:6][N:7]([CH3:9])[CH3:8].[BrH:16].C(O)(=O)C>>[BrH:16].[CH3:9][N:7]([CH2:6][C:5]1[C:4]([CH2:13][CH2:14][CH3:15])=[C:3]([OH:2])[CH:12]=[CH:11][CH:10]=1)[CH3:8]参加物
3
実験手順
(3-Methoxy-2-propylbenzyl)-dimethylamine (1.51 g, 7.28 mmol) was suspended in 30% hydrogen bromide/acetic acid (10 mL) and heated to reflux with stirring for 20 h. The cooled reaction mixture was triturated and decanted with successive portions of diethyl ether (4×), then triturated with diethyl ether overnight. The solid was collected by filtration, washed with ether and dried to give 3-dimethylaminomethyl-2-propylphenol hydrobromide (1.58 g, 79%) as a tan solid.
後処理
- temperatureheated
- temperatureto reflux
- customThe cooled reaction mixture
- customwas triturated
- customdecanted with successive portions of diethyl ether (4×)
- customtriturated with diethyl ether overnight
- filtrationThe solid was collected by filtration
- washwashed with ether
- customdried
出典と根拠
- ORDレコード
- ord-74da8df2f07e4738a44d503a6889cf73
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07276528B2
反応ノート
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