Hydrogen Peroxide → 1-(2,4-Dichlorophenyl)cyclopropane-1-carboxamide
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:12]#[N:13])[CH2:11][CH2:10]1.C(=O)([O-])[O-:15].[K+].[K+].OO.O>CS(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:12]([NH2:13])=[O:15])[CH2:10][CH2:11]1参加物
6
反応条件
- 温度
- 0 °C
実験手順
1-(2,4-Dichloro-phenyl)-cyclopropanecarbonitrile (2.1 g, 10 mmol) was dissolved in DMSO (10 ml) and the solution cooled to 0° C. using an ice bath. Potassium carbonate (0.2 g, 1.5 mmol) was then added, followed by commercial 30% aqueous hydrogen peroxide (2 mL). The reaction was then allowed to warm to room temperature with stirring over 1 h. Water (20 mL) was added and the 1-(2,4-dichloro-phenyl)-cyclopropanecarboxylic acid amide collected as a white solid. Yield: 2.1 g (90%).
後処理
- temperatureto warm to room temperature
- customthe 1-(2,4-dichloro-phenyl)-cyclopropanecarboxylic acid amide collected as a white solid
出典と根拠
- ORDレコード
- ord-72b789f8c7c545fe97e9fae1c76b39ff
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07276526B2
反応ノート
読み込み中…