Ammonia → 1-[4-(Trifluoromethyl)pyridin-3-yl]methanamine

HRID 1178929ノート

反応式

HRID 1178929 の反応式
[F:1][C:2]([F:12])([F:11])[C:3]1[C:8]([C:9]#[N:10])=[CH:7][N:6]=[CH:5][CH:4]=1.N>[Ni].C(O)C>[F:11][C:2]([F:1])([F:12])[C:3]1[CH:4]=[CH:5][N:6]=[CH:7][C:8]=1[CH2:9][NH2:10]

参加物

5

反応物 2

HCID 222AmmoniaHCID 27367434-(Trifluoromethyl)pyridine-3-carbonitrile

生成物 1

HCID 35238171-[4-(Trifluoromethyl)pyridin-3-yl]methanamine収率 98%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

Add Raney nickel (0.5 g) to a solution of 4-trifluoromethyl-nicotinonitrile (1.0 g, 5.8 mmol) in ethanol saturated with ammonia (20.0 mL) and shake under hydrogen at 500 psi for 1 hour. Filter reaction, concentrate the filtrate, and dry the solid obtained to give the title compound (1.0 g, 98%). MS (ES) 177.0 (M+1)+.

後処理

  1. filtrationFilter
  2. customreaction
  3. concentrationconcentrate the filtrate
  4. customdry the solid
  5. customobtained

出典と根拠

ORDレコード
ord-16e301fd60794bc2a858199ba8a5afec
出典データセット
uspto-grants-2007_10
特許番号
US07276516B2

反応ノート

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