関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Acetonitrile | HCID 6342 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | trans-1,2-Indandiol | HCID 247603 | — |
| 生成物 | (1R,2S)-(+)-cis-1-Amino-2-indanol | HCID 2725045 | 63% |
反応手順
Trans-1,2-indandiol (1.5 g) was dissolved in acetonitrile (25 mL) cooled to 0° C., and concentrated sulfuric acid (1.1 mL) was added. The mixture was gradually warmed to 20° C. and aged to 3 hours. Water (2 mL) was added and the mixture heated to reflux. Concentrated aqueous sodium hydroxide was added to adjust the pH to 12. The resulting solid was removed by filtration to provide an aqueous acetonitrile solution of cis-1-amino-2-indanol (1.02 g, 63% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05723615 |
|---|
| 出典データセット | uspto-grants-1998_03 |
|---|
| ORD ID | ord-0d0c32a5746a47be8dab7284d54a01f0 |
|---|
| 出典メモ | uspto-grants-1998_03 |
|---|
