Sodium Methoxide → Methyl 4-Hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

HRID 1179324ノート

反応式

HRID 1179324 の反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]([NH:7][C:8]1[C:9]([C:14]([O:16]C)=O)=[N:10][CH:11]=[CH:12][CH:13]=1)=[O:6].C[O-].[Na+]>>[OH:16][C:14]1[C:9]2[C:8](=[CH:13][CH:12]=[CH:11][N:10]=2)[NH:7][C:5](=[O:6])[C:4]=1[C:3]([O:2][CH3:1])=[O:18]

参加物

3

反応物 2

HCID 10942334Sodium Methoxide2 回HCID 42637833Methyl 3-[(3-methoxy-3-oxopropanoyl)amino]pyridine-2-carboxylate

生成物 1

HCID 54729994Methyl 4-Hydroxy-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carboxylate

実験手順

To a solution of methyl 3-[(3-methoxy-3-oxopropanoyl)amino]pyridine-2-carboxylate (7.3 g, 29.9 mmol, prepared as described in example 1) in anhydrous TBF (100 mL) was added solid sodium methoxide (3.9 g, 72.4 mmol) at 0° C. Immediately following the addition of the sodium methoxide, solids crashed out of the solution. The ice bath was then removed and the suspension was stirred for an additional 0.5 hours. The suspension was then filtered through a medium porosity filtration funnel to afford yellow solids.

後処理

  1. customThe ice bath was then removed
  2. filtrationThe suspension was then filtered through a medium porosity filtration funnel
  3. customto afford yellow solids

出典と根拠

ORDレコード
ord-f10dd82cdede403fb719c0f1b365ec62
出典データセット
uspto-grants-2007_10
特許番号
US07279487B2

反応ノート

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