Water → 4-[4-(Hydroxymethyl)piperidin-1-yl]benzaldehyde
反応式
F[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=1.[OH:10][CH2:11][CH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.C(=O)([O-])[O-].[Cs+].[Cs+].O>CN(C=O)C>[OH:10][CH2:11][CH:12]1[CH2:17][CH2:16][N:15]([C:2]2[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[CH:4][CH:3]=2)[CH2:14][CH2:13]1参加物
6
反応条件
- 温度
- 100 °C
実験手順
A suspension of 4-fluorobenzaldehyde (4.3 mL), 4-hydroxymethylpiperidine (4.8 g), and cesium carbonate (26 g) in DMF (80 mL) was heated to 100° C. for 24 h and cooled to room temperature. Water (400 mL) was added, and the resulting precipitate was collected by filtration to give the title compound as a tan amorphous powder (4.1 g).
後処理
- temperaturecooled to room temperature
- filtrationthe resulting precipitate was collected by filtration
出典と根拠
- ORDレコード
- ord-eece5a71b93c41c7b2457cced25857be
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07279491B2
反応ノート
読み込み中…