Phosphate → Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester

HRID 1179727ノート

反応式

HRID 1179727 の反応式
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[S:6][CH:7]=1.[CH3:15][N:16]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:17](Cl)=[O:18].P([O-])([O-])([O-])=O>>[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([C:8]2[CH:13]=[CH:12][C:11]([O:14][C:17](=[O:18])[N:16]([CH3:15])[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[CH:10][CH:9]=2)[S:6][CH:7]=1

参加物

4

反応物 3

HCID 1061PhosphateHCID 77969Carbamic chloride, N-methyl-N-phenyl-HCID 6055044-[4-(Chloromethyl)-1,3-thiazol-2-yl]phenol

生成物 1

HCID 10172371Methyl-phenyl-carbamic Acid 4-(4-chloromethyl-thiazol-2-yl)-phenyl Ester

実験手順

The title compound was prepared from 4-(4-chloromethyl-thiazol-2-yl)-phenol and N-methyl-N-phenylcarbamoyl chloride. The aqueous phase was adjusted to PH 7.0 (phosphate buffer), before extraction with ethyl acetate. The crude product was subjected to preparative HPLC (21%, white crystals). HPLC-MS m/z=359.0 (M+1), Rt: 4.60.

後処理

  1. extractionbefore extraction with ethyl acetate

出典と根拠

ORDレコード
ord-f81fbb8ec051415181e64f506977887b
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

反応ノート

読み込み中…