Benzyl 4-hydroxyphenyl ketone → Methyl-phenyl-carbamic Acid 4-phenylacetyl-phenyl Ester

反応式

[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:9])=[CH:4][CH:3]=1.[CH3:17][N:18]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:19](Cl)=[O:20]>>[C:11]1([CH2:10][C:8]([C:5]2[CH:4]=[CH:3][C:2]([O:1][C:19](=[O:20])[N:18]([CH3:17])[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:7][CH:6]=2)=[O:9])[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

反応物 2

HCID 75607Benzyl 4-hydroxyphenyl ketone

HCID 77969Carbamic chloride, N-methyl-N-phenyl-

生成物 1

HCID 69518528Methyl-phenyl-carbamic Acid 4-phenylacetyl-phenyl Ester

実験手順

The title product was prepared from benzyl 4-hydroxyphenyl ketone and N-methyl-N-phenylcarbamoyl chloride. The crude product was subjected to preparative HPLC (68%, light yellow oil). HPLC-MS: m/z=431.2 (M+1); Rt: 3.55 min.

出典と根拠

ORDレコード: ord-fc35d5474c0d476392a928f5d3a6726c
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07279470B2

反応ノート

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