Cyclopropylamine → Methyl-phenyl-carbamic Acid 4-cyclopropylcarbamoyl-phenyl Ester

HRID 1179846ノート

反応式

HRID 1179846 の反応式
O=C1CCC(=O)N1O[C:9](=[O:27])[C:10]1[CH:15]=[CH:14][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[CH:12][CH:11]=1.[CH:28]1([NH2:31])[CH2:30][CH2:29]1>>[CH:28]1([NH:31][C:9]([C:10]2[CH:11]=[CH:12][C:13]([O:16][C:17](=[O:26])[N:18]([CH3:25])[C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)=[CH:14][CH:15]=2)=[O:27])[CH2:30][CH2:29]1

参加物

3

反応物 2

HCID 69828CyclopropylamineHCID 865892064-(Methyl-phenyl-carbamoyloxy)-benzoic Acid 2,5-dioxo-pyrrolidin-1-yl Ester

生成物 1

HCID 69517581Methyl-phenyl-carbamic Acid 4-cyclopropylcarbamoyl-phenyl Ester

実験手順

The title product was prepared from 4-(methyl-phenyl-carbamoyloxy)-benzoic acid 2,5-dioxo-pyrrolidin-1-yl ester and cyclopropylamine. The crude product was used without further purification (97%, oil). HPLC-MS: m/z=311.2 (M+1); Rt: 3.21 min.

後処理

  1. customThe crude product was used without further purification (97%, oil)

出典と根拠

ORDレコード
ord-d2ffc520a0c442b9afe624dfc0c92877
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

反応ノート

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