4-Morpholinecarbonyl chloride → Morpholine-4-carboxylic Acid imidazol-1-yl Ester

反応式

[OH:1][N:2]1[CH:6]=[CH:5][N:4]=[CH:3]1.[N:7]1([C:13](Cl)=[O:14])[CH2:12][CH2:11][O:10][CH2:9][CH2:8]1>>[N:2]1([O:1][C:13]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)=[O:14])[CH:6]=[CH:5][N:4]=[CH:3]1

参加物

反応物 2

HCID 848104-Morpholinecarbonyl chloride

HCID 36143511-Hydroxyimidazole

生成物 1

HCID 45091617Morpholine-4-carboxylic Acid imidazol-1-yl Ester

実験手順

The title compound was prepared from 1-hydroxyimidazole and 4-morpholine carbonyl chloride applying the general procedure 8. The crude product was purified by preparative HPLC (water-acetonitrile-0.1% TFA) (36%, crystals).

後処理

customThe crude product was purified by preparative HPLC (water-acetonitrile-0.1% TFA) (36%, crystals)

出典と根拠

ORDレコード: ord-1caa7575090940caa7492842f2c0aa30
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07279470B2

反応ノート

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