Potassium Bromide → 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

HRID 1179954

反応式

HRID 1179954 の反応式
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([O:11][C:12]2[C:17]([Cl:18])=[CH:16][C:15]([C:19]([F:22])([F:21])[F:20])=[CH:14][N:13]=2)=[CH:7][CH:6]=1)=[O:3].[CH:23]1([CH2:26][N:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[CH2:25][CH2:24]1.[K+].[Br-]>>[Cl:18][C:17]1[C:12]([O:11][C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:30]3[CH2:31][CH2:32][N:27]([CH2:26][CH:23]4[CH2:25][CH2:24]4)[CH2:28][CH2:29]3)=[O:3])=[CH:6][CH:7]=2)=[N:13][CH:14]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:16]=1

参加物

4

反応物 3

HCID 253877Potassium BromideHCID 9658751-(Cyclopropylmethyl)piperazineHCID 220476914-(3-Chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate

生成物 1

HCID 695190634-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3-chloro-5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester

実験手順

The hydrochloride of the title compound was prepared from 4-(3-chloro-5-trifluoromethylpyridin-2-yloxy)-phenyl chloroformate and 1-cyclopropylmethyl-piperazine, yield 83%. White crystals, m.p. 254-255° C.; IR (KBr): ν 1728 (C═O) cm−1.

出典と根拠

ORDレコード
ord-2c75ef7872ac46a9a89578df91f98a44
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

関連ノート

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