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Diisopropylamine → 4-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | 1-(Piperidin-4-yl)-1H-benzotriazole--hydrogen chloride (1/1) | HCID 2779380 | — |
| 反応物 | 4-(5-Trifluoromethylpyridin-2-yloxy)-phenyl chloroformate | HCID 22047762 | — |
| 生成物 | 4-Benzotriazol-1-yl-piperidine-1-carboxylic Acid 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl Ester | HCID 69520407 | — |
反応手順
The title compound was prepared from 4-(5-trifluoromethyl-pyridin-2-yloxy)-phenyl chloroformate and 1-piperidin-4-yl-1 H-benzotriazole, hydrochloride, 5 equivalent of diisopropylamine was added, preparative HPLC (Method C) (7%, colourless crystals). HPLC-MS m/z=506.2 (M+1), Rt: 4.56 min.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07279470B2 |
| 出典データセット | uspto-grants-2007_10 |
| ORD ID | ord-1a330739b88542b1bd13f7750a486880 |
| 出典メモ | uspto-grants-2007_10 |