1-(Cyclopropylmethyl)piperazine → 4-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

HRID 1180006

反応式

HRID 1180006 の反応式
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[CH2:3][CH2:2]1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21](=[O:29])[NH:22][CH2:23][CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[CH:17][CH:16]=1)=[O:13]>ClCCl>[CH3:26][C:25]([CH3:28])([CH3:27])[CH2:24][CH2:23][NH:22][C:21]([C:18]1[CH:17]=[CH:16][C:15]([O:14][C:12]([N:8]2[CH2:9][CH2:10][N:5]([CH2:4][CH:1]3[CH2:3][CH2:2]3)[CH2:6][CH2:7]2)=[O:13])=[CH:20][CH:19]=1)=[O:29]

参加物

4

反応物 2

HCID 9658751-(Cyclopropylmethyl)piperazineHCID 220478734-(3,3-Dimethyl-butylcarbamoyl)-phenyl chloroformate

生成物 1

HCID 695182864-Cyclopropylmethyl-piperazine-1-carboxylic Acid 4-(3,3-dimethyl-butylcarbamoyl)-phenyl Ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The title product was prepared from 1-cyclopropylmethylpiperazine (0.35 mmol) dissolved in dichloromethane (5 ml). 4-(3,3-dimethyl-butylcarbamoyl)-phenyl chloroformate (0.35 mmol) was added at room temperature. The reaction mixture was stirred for 16 h and evaporated to dryness and subjected to preparative HPLC (method C) (5%, white crystals). HPLC-MS m/z=388.2 (M+1), Rt: 2.43 min.

後処理

  1. customevaporated to dryness

出典と根拠

ORDレコード
ord-aa92688ed1e24daba7e9db4001d7e584
出典データセット
uspto-grants-2007_10
特許番号
US07279470B2

関連ノート

読み込み中…