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Nicotinic Acid → Methyl-phenyl-carbamic Acid 4-{2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nicotinic Acid | HCID 938 | — |
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| 反応物 | Methyl-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl Ester | HCID 69520583 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl-phenyl-carbamic Acid 4-{2-[(pyridine-3-carbonyl)-amino]-ethyl}-phenyl Ester | HCID 69517683 | 15% |
反応手順
A solution of 3-pyridinecarboxylic acid (0.3 mmol), EDAC (0.36 mmol) and triethylamine (0.36 mmol) in CH2Cl2 (10 mL) was added N-hydroxybenzoetriazole and N-methyl-N-phenyl-carbamic acid 4-(2-amino-ethyl)phenyl ester as its TFA salt (0.3 mmol). The mixture was stir-stirred 16 h at rt and purified by preparative HPLC (Gilson) to give the title compound in 15% yield as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07279470B2 |
| 出典データセット | uspto-grants-2007_10 |
| ORD ID | ord-dfcf06294c9041219636b8986f5ec125 |
| 出典メモ | uspto-grants-2007_10 |