Tyrosol → Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester

関与物質

役割	名称	HCID	仕込み量
反応物	Tyrosol	HCID 10393	—
反応物	Carbamic chloride, N-methyl-N-phenyl-	HCID 77969	—
溶媒	Dichloromethane	HCID 6344	—
生成物	Methyl-phenyl-carbamic Acid 4-(2-hydroxy-ethyl)-phenyl Ester	HCID 69520342	99.1%

反応手順

To a solution of 4-(2-Hydroxyethyl)phenol (10 mmol) and 4-diazabicyclo[2.2.2]octane (DABCO) (10 mmol) in CH2Cl2 (30 mL) was added N-methyl-N-phenylcarbamoyl chloride (10 mmol). The reaction mixture was stirred for 16 hours at rt, added CH2Cl2 (20 mL), and washed with 1M aqueous HCl and brine. The organic phase was dried (MgSO4) and evaporated to give the 2.69 g (99%) of the title compound as crystals.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07279470B2
出典データセット	uspto-grants-2007_10
ORD ID	ord-7cb4b87fd2f641f0985c21c6fa665b9f
出典メモ	uspto-grants-2007_10