化工社化工社 化学情報印刷レポート · 研究参考用
Benzoic Acid → Rizatriptan Benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzoic Acid | HCID 243 | — |
| 反応物 | Rizatriptan | HCID 5078 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 溶媒 | Isopropyl Acetate | HCID 7915 | — |
| 生成物 | Rizatriptan Benzoate | HCID 77997 | 80.1% |
反応手順
A solution of 147 mg (1.2 mmoles) of benzoic acid in 1 ml of isopropyl acetate was added slowly to a solution of 300 mg (1.1 mmoles) of the rizatriptan base in 2.6 ml of isopropyl alcohol. The mixture was stirred at room temperature for 30 minutes and evaporated to dryness, and the residue recrystallised from ethanol to give 345 mg (80%) of rizatriptan benzoate as a white crystalline solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07279581B2 |
| 出典データセット | uspto-grants-2007_10 |
| ORD ID | ord-abd210887dcd46259279e7ded4ab972d |
| 出典メモ | uspto-grants-2007_10 |