Methyl 2-bromo-4-methylpentanoate → HCID 69472556、化合物

反応式

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Br[CH:16]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:17]([O:19][CH3:20])=[O:18]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[O:9][CH:16]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:6][CH:7]=1

参加物

反応物 2

HCID 12957039Methyl 2-bromo-4-methylpentanoate

HCID 14949088(4-Bromophenyl)(thiazol-2-yl)methanol

生成物 1

HCID 69472556HCID 69472556、化合物

実験手順

Using the same protocol as described in example 23, step 2, (4-bromophenyl)(1,3-thiazol-2-yl)methanol from step 1 (983 mg, 3.64 mmol) was added to methyl 2-bromo-4-methylpentanoate (624 μL, 3.82 mmol). The crude residue was chromatographed on silica gel using 25% ethyl acetate in hexanes to afford the title compound.

後処理

customThe crude residue was chromatographed on silica gel using 25% ethyl acetate in hexanes

出典と根拠

ORDレコード: ord-bfa3453ddb734985a328f0a4fafdaf5d
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07279478B2

反応ノート

読み込み中…

参加物