1,3-Dichloro-5,5-dimethylhydantoin → HCID 22053547、化合物

HRID 1180504ノート

反応式

HRID 1180504 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][CH:7]=1.[Cl:22]N1C(C)(C)C(=O)N(Cl)C1=O>ClCCl>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH2:14][CH2:13][CH2:12][N:11]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:10][CH2:9]2)[CH:5]=[N:6][C:7]=1[Cl:22]

参加物

4

反応物 2

HCID 83601,3-Dichloro-5,5-dimethylhydantoinHCID 11507869HCID 11507869、化合物

生成物 1

HCID 22053547HCID 22053547、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of 1-(5-chloro-3-pyridyl)-4-tert-butoxycarbonylhomopiperazine (1.56, 5.0 mmol), 1,3-dichloro-5,5-dimethylhydantoin (0.985 g, 5.0 mmol) and dichloromethane (50 ml) was stirred for 180 minutes. The crude mixture was evaporated and purified by chromatography on silica gel using ethyl acetate:petroleum (3:1) as solvent. Yield 0.46 g, 27%.

後処理

  1. customThe crude mixture was evaporated
  2. custompurified by chromatography on silica gel

出典と根拠

ORDレコード
ord-9f29675c18b6431a9681844ef170fd37
出典データセット
uspto-grants-2007_10
特許番号
US07282494B2

反応ノート

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