2-((4-Chlorophenyl)(4-piperidinyloxy)methyl)pyridine → 2-((4-Chlorophenyl)(piperidin-4-yloxy)methyl)pyridine, (S)-
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[O:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)=[CH:4][CH:3]=1.O[C@@H]([C@@H](C1C=CC(OC)=CC=1)SC1C=CC=CC=1[N+]([O-])=O)C(O)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)[O:9][CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)=[CH:4][CH:3]=1参加物
3
実験手順
By treating (±)-4-[(4-chlorophenyl)(2-pyridyl)-methoxy]piperidine and (2R,3R)-2-hydroxy-3-(4-methoxy-phenyl)-3-(2-nitrophenylthio)propionic acid in the same manner as in Example 4-(1), (2) and (3) to afford (S)-4-[(4-chlorophenyl)(2-pyridyl)methoxy]piperidine.
出典と根拠
- ORDレコード
- ord-18bf3ceeecc244209040b11513454390
- 出典データセット
- uspto-grants-2007_10