Acetone → 5-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone

HRID 1180660ノート

反応式

HRID 1180660 の反応式
[CH3:1][C:2]([CH3:4])=[O:3].S(=O)(=O)(O)O.[O:10]=[C:11]1[O:17][C@H:16]([C@H:18]([CH2:20]O)[OH:19])[C:14]([OH:15])=[C:12]1[OH:13]>>[CH3:1][C:2]1([CH3:4])[O:19][CH:18]([CH:16]2[O:17][C:11](=[O:10])[C:12]([OH:13])=[C:14]2[OH:15])[CH2:20][O:3]1

参加物

4

反応物 3

HCID 180AcetoneHCID 1118Sulfuric AcidHCID 54670067L-Ascorbic Acid

生成物 1

HCID 546765085-(2,2-dimethyl-1,3-dioxolan-4-yl)-3,4-dihydroxy-2(5H)-furanone収率 115.4%

実験手順

With nitrogen substitution, 557.8 grams (9.6 moles) of acetone was cooled to −5 degrees C., 54.3 grams (0.2 moles) of 28% fuming sulfuric acid was dripped, and 176.1 grams (1.0 mole) of L-ascorbic acid was added. The mixture was then reacted at the temperature of the previous step for 17 hours, filtered and washed with cold acetone to obtain 249.5 grams of 5,6-O-isopropylidene-L-ascorbic acid (86.7% in purity) in the form of a wet cake.

後処理

  1. customThe mixture was then reacted at the temperature of the previous step for 17 hours
  2. filtrationfiltered
  3. washwashed with cold acetone

出典と根拠

ORDレコード
ord-965491601e2945cfa1184eb44092dbea
出典データセット
uspto-grants-2007_10
特許番号
US07282597B2

反応ノート

読み込み中…