Phosphorus tribromide → N9-phenethyl-8-bromomethyladenine

HRID 1181200ノート

反応式

HRID 1181200 の反応式
[CH2:1]([N:9]1[C:17]([CH2:18]O)=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:20])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.P(Br)(Br)[Br:22]>C(Cl)Cl>[CH2:1]([N:9]1[C:17]([CH2:18][Br:22])=[N:16][C:15]2[C:10]1=[N:11][CH:12]=[N:13][C:14]=2[NH2:20])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24614Phosphorus tribromideHCID 42637018N9-phenethyl-8-hydroxymethyladenine

生成物 1

HCID 42637845N9-phenethyl-8-bromomethyladenine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of N9-phenethyl-8-hydroxymethyladenine (1 mmol) in methylene chloride was treated with phosphorus tribromide (1 mmol) at 25° C. for 1 h. Extraction and chromatography gave N9phenethyl-8-bromomethyl-adenine as a white solid. TLC: Rf=0.31, 10% MeOH—CH2Cl2.

後処理

  1. extractionExtraction and chromatography

出典と根拠

ORDレコード
ord-230207b0987b46ac9eae92b8f3039d9d
出典データセット
uspto-grants-2007_10
特許番号
US07285543B2

反応ノート

読み込み中…