Acetic Anhydride → Methyl 3-(formylamino)-2-thiophenecarboxylate

HRID 1181266ノート

反応式

HRID 1181266 の反応式
[C:1](OC(=O)C)(=[O:3])C.[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH2:17])=[O:11]>C(O)=O>[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH:17][CH:1]=[O:3])=[O:11]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

生成物 1

HCID 2777636Methyl 3-(formylamino)-2-thiophenecarboxylate収率 85%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

Formic acid (40 mL) was added to acetic anhydride (60 mL) while cooling in an ice bath. Solid 3-amino-2-thiophenecarboxylic acid methyl ester (77, 10.3 g, 66 mmol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-2-thiophenecarboxylic acid methyl ester (10.3 g, 85% yield) as a white solid.

後処理

  1. temperaturewhile cooling in an ice bath
  2. customThe cooling bath was removed
  3. additionThe reaction mixture was diluted with water (100 mL)
  4. filtrationthe solid product collected by vacuum filtration

出典と根拠

ORDレコード
ord-7320ef1d783641bd85b7826d235b9f9c
出典データセット
uspto-grants-2007_10
特許番号
US07285556B2

反応ノート

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