Hydrogen Peroxide → 4-(tert-Butyl)pyridine 1-Oxide
反応式
[C:1]([C:5]1[CH:10]=[CH:9][N:8]=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[OH:11]O>C(O)(=O)C>[C:1]([C:5]1[CH:10]=[CH:9][N+:8]([O-:11])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]参加物
4
実験手順
To a solution of 4-tert-butylpyridine (44.3 ml, 300 mmol) in glacial acetic acid (200 ml) was added hydrogen peroxide (37.1 ml of a 27.5% aqueous solution, 300 mmol), and the resulting mixture heated at reflux overnight. The cooled mixture was evaporated to dryness. The residue was dissolved in dichloromethane (200 ml), and washed with brine (50 ml), then dried (Na2SO4) and evaporated to give the title compound (40 g, 88%) as a white solid.
後処理
- temperatureheated
- temperatureat reflux overnight
- customThe cooled mixture was evaporated to dryness
- dissolutionThe residue was dissolved in dichloromethane (200 ml)
- washwashed with brine (50 ml)
- dry with materialdried (Na2SO4)
- customevaporated
出典と根拠
- ORDレコード
- ord-29a7064d6cf04d8ea08346aa4f2b6e70
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07285563B2
反応ノート
読み込み中…