Water → 2-Methoxy-4-(trifluoromethyl)benzonitrile

HRID 1181424

反応式

HRID 1181424 の反応式
[N+]([C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-])=O.[CH3:16][O-:17].[Na+].O>CO>[CH3:16][O:17][C:4]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

参加物

5

反応物 3

HCID 962WaterHCID 699022-Nitro-4-(trifluoromethyl)benzonitrileHCID 10942334Sodium Methoxide

生成物 1

HCID 190013762-Methoxy-4-(trifluoromethyl)benzonitrile収率 91%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a solution of 2-nitro-4-(trifluoromethyl)benzonitrile (22.48 g, 104 mmol) in anhydrous methanol (110 ml) was added dropwise 25% sodium methoxide in methanol (24.72 ml, 114.4 mmol), and the resulting mixture stirred at room temperature for 1 hour. Water (110 ml) was added and the resulting solids collected by filtration. The solids were dissolved in DCM (150 ml), washed with sat NaCl (75 ml), dried over Na2SO4, filtered and evaporated to give the title compound (19 g, 91%) as a white solid.

後処理

  1. filtrationthe resulting solids collected by filtration
  2. dissolutionThe solids were dissolved in DCM (150 ml)
  3. washwashed with sat NaCl (75 ml)
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customevaporated

出典と根拠

ORDレコード
ord-c429fac802f345ae93bd22b24c07a7e3
出典データセット
uspto-grants-2007_10
特許番号
US07285563B2

関連ノート

読み込み中…