Nitric Acid → 5-Nitroisoquinoline-1-carboxylic acid

HRID 1181428

反応式

HRID 1181428 の反応式
[C:1]1([C:11]([OH:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.[N+:14]([O-])([OH:16])=[O:15]>S(=O)(=O)(O)O>[N+:14]([C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[CH:4]=[CH:3][N:2]=[C:1]2[C:11]([OH:13])=[O:12])([O-:16])=[O:15]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 68092Isoquinoline-1-carboxylic acid

生成物 1

HCID 2856465-Nitroisoquinoline-1-carboxylic acid収率 82%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

反応条件

温度
0 °C

実験手順

Isoquinoline-1-carboxylic acid (3.98 g, 23.0 mmol) was dissolved in conc. sulfuric acid (16 ml) at 0° C. A mixture of conc. sulfuric acid (5 ml) and fuming nitric acid (5 ml) was added over 10 min. and the reaction stirred for a further 1 h at 0° C., then poured into ice-water (400 ml). The solid was collected by filtration, then washed with water (100 ml), ethanol (100 ml) and ether (100 ml), then dried under vacuum to give the title compound (4.1 g, 82%).

後処理

  1. additionwas added over 10 min.
  2. filtrationThe solid was collected by filtration
  3. washwashed with water (100 ml), ethanol (100 ml) and ether (100 ml)
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-5a14113c17d045dfa70c11d5175d45d3
出典データセット
uspto-grants-2007_10
特許番号
US07285563B2

関連ノート

読み込み中…