alpha-Chloro-o-xylene → 5-methyl-7-(2-methylbenzyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181679

反応式

HRID 1181679 の反応式
Cl[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH3:9].C(=O)([O-])[O-].[K+].[K+].[CH3:16][N:17]1[C:22](=[O:23])[C:21]2=[C:24]([C:38]3[CH:43]=[CH:42][N:41]=[CH:40][CH:39]=3)[N:25]([CH2:27][C:28]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=[CH:30][CH:29]=3)[N:26]=[C:20]2[NH:19][C:18]1=[O:44]>>[CH3:16][N:17]1[C:22](=[O:23])[C:21]2=[C:24]([C:38]3[CH:39]=[CH:40][N:41]=[CH:42][CH:43]=3)[N:25]([CH2:27][C:28]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH:31]=[CH:30][CH:29]=3)[N:26]=[C:20]2[N:19]([CH2:2][C:3]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[CH3:9])[C:18]1=[O:44]

参加物

4

反応物 3

HCID 11093alpha-Chloro-o-xyleneHCID 11430Potassium CarbonateHCID 1363341135-methyl-2-(1-naphthylmethyl)-3-(4-pyridinyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

生成物 1

HCID 589809815-methyl-7-(2-methylbenzyl)-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

反応条件

温度
80 °C

実験手順

1-(chloromethyl)-2-methylbenzene (0.045 ml) and potassium carbonate (0.6 g) were added to a solution of 5-methyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (2 ml). The mixture was heated at 80° C. for 18 hours then cooled to room temperature. Solids removed by filtration and the crude product was purified on preparative HPLC to give the title compound (0.057 g). Mass: 487.87 (M+H).

後処理

  1. temperaturethen cooled to room temperature
  2. customSolids removed by filtration
  3. customthe crude product was purified on preparative HPLC

出典と根拠

ORDレコード
ord-e049f699c79d419ba37b8ffd2f9eebcf
出典データセット
uspto-grants-2007_10
特許番号
US07285558B2

関連ノート

読み込み中…