Triethylamine → 3-[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid

HRID 1181680ノート

反応式

HRID 1181680 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[CH:6]=[C:5]([NH:9][N:10]=[CH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[NH:4][C:3]1=[O:22].C(N(CC)CC)C.[CH:30]([C:32]1[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=1)[C:35]([OH:37])=[O:36])=O>CN(C)C=O>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2=[C:30]([C:32]3[CH:33]=[C:34]([CH:38]=[CH:39][CH:40]=3)[C:35]([OH:37])=[O:36])[N:10]([CH2:11][C:12]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:15]=[CH:14][CH:13]=3)[N:9]=[C:5]2[NH:4][C:3]1=[O:22]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 120773-CarboxybenzaldehydeHCID 698455281-Naphthaldehyde (1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone

生成物 1

HCID 1363341153-[5-methyl-2-(1-naphthylmethyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-3-yl]benzoic acid

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

1-naphthaldehyde (1-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)hydrazone (2.12 g) and triethylamine (0.8 ml) was added to a suspension of Resin bound 3-formylbenzoic acid in dimethylformamide (15 ml), and the mixture was shaken at 90° C. for 16 hours. The resin was filtered and washed (3 times) DMF, CH2Cl2, MeOH, CH2Cl2, and dried in vacuum to give the subtitle compound.

後処理

  1. filtrationThe resin was filtered
  2. washwashed (3 times) DMF, CH2Cl2, MeOH, CH2Cl2
  3. customdried in vacuum

出典と根拠

ORDレコード
ord-d0dd19257cd84a4faa51d8b762041751
出典データセット
uspto-grants-2007_10
特許番号
US07285558B2

反応ノート

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