1-Bromo-2-methylpropane → 5-methyl-2-(1-naphthylmethyl)-7-neopentyl-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181747

反応式

HRID 1181747 の反応式
[CH3:1][N:2]1[C:7](=[O:8])[C:6]2=[C:9]([C:23]3[CH:28]=[CH:27][N:26]=[CH:25][CH:24]=3)[N:10]([CH2:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=[CH:15][CH:14]=3)[N:11]=[C:5]2[NH:4][C:3]1=[O:29].Br[CH2:31][CH:32]([CH3:34])[CH3:33].[CH2:35]1CCN2C(=NCCC2)CC1>CN(C=O)C>[CH3:1][N:2]1[C:7](=[O:8])[C:6]2=[C:9]([C:23]3[CH:24]=[CH:25][N:26]=[CH:27][CH:28]=3)[N:10]([CH2:12][C:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH:16]=[CH:15][CH:14]=3)[N:11]=[C:5]2[N:4]([CH2:31][C:32]([CH3:34])([CH3:35])[CH3:33])[C:3]1=[O:29]

参加物

5

反応物 3

HCID 65551-Bromo-2-methylpropaneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 1363341135-methyl-2-(1-naphthylmethyl)-3-(4-pyridinyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

生成物 1

HCID 589810765-methyl-2-(1-naphthylmethyl)-7-neopentyl-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

This compound was synthesized by the reaction of 5-methyl-2-(1-naphthylmethyl)-3-pyridin-4-yl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and 1-bromo-2-methylpropane using DBU as abase in DMF at 100° C. Mass: 454.36 (M+H).

後処理

  1. customat 100° C

出典と根拠

ORDレコード
ord-943e9caeb6a9418989d3fc01f4dc0a6e
出典データセット
uspto-grants-2007_10
特許番号
US07285558B2

関連ノート

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