4-(2-Chloroethyl)morpholine → 2-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-5-(2-morpholin-4-ylethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[CH2:12][N:13]1[C:21]([C:22]2[N:26]([CH3:27])[CH:25]=[N:24][N:23]=2)=[C:20]2[C:15]([N:16]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:17](=[O:29])[NH:18][C:19]2=[O:28])=[N:14]1.Cl[CH2:35][CH2:36][N:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[CH:7][CH:6]=[C:5]2[CH2:12][N:13]1[C:21]([C:22]2[N:26]([CH3:27])[CH:25]=[N:24][N:23]=2)=[C:20]2[C:15]([N:16]([CH2:30][CH:31]([CH3:33])[CH3:32])[C:17](=[O:29])[N:18]([CH2:35][CH2:36][N:37]3[CH2:42][CH2:41][O:40][CH2:39][CH2:38]3)[C:19]2=[O:28])=[N:14]1

参加物

反応物 2

HCID 767274-(2-Chloroethyl)morpholine

HCID 589810832-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

生成物 1

HCID 589811622-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-5-(2-morpholin-4-ylethyl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

実験手順

This compound was made by alkylation of 2-[(6-chloroquinolin-4-yl)methyl]-7-isobutyl-3-(4-methyl-4H-1,2,4-triazol-3-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione with 4-(2-chloroethyl)morpholine following conditions in Example 6.d. 578.2 (M+H).

出典と根拠

ORDレコード: ord-c8fe0d8c96d5430383812192988945e0
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07285558B2

反応ノート

読み込み中…