Ethyl Acrylate → HCID 58980622、化合物

反応式

[C:1]([C:5]1O[C:7]([O:10]CC)=[CH:8][N:9]=1)([CH3:4])([CH3:3])[CH3:2].[C:13]([O:17][CH2:18][CH3:19])(=[O:16])[CH:14]=[CH2:15]>>[CH2:18]([O:17][C:13](=[O:16])[C:14]1[C:7]([OH:10])=[CH:8][N:9]=[C:5]([C:1]([CH3:2])([CH3:3])[CH3:4])[CH:15]=1)[CH3:19]

参加物

反応物 2

HCID 8821Ethyl Acrylate

HCID 12634259HCID 12634259、化合物

生成物 1

HCID 58980622HCID 58980622、化合物収率 54%

反応条件

温度: 100 °C

実験手順

2-tert-Butyl-5-ethoxy-oxazole (16.6 g, 98.1 mmol) was dissolved in freshly distilled ethyl acrylate (11.7 mL, 108 mmol). The solution was heated in a sealed tube to 100° C. for 24 h. Upon cooling, the remaining starting materials were distilled away from the product which was further purified by filtration through a plug of silica-gel (methylene chloride) and concentrated to provide 2-tert-butyl-5-hydroxy-isonicotinic acid ethyl ester (11.2 g, 54%) as a pale yellow oil.

後処理

temperatureUpon cooling
distillationthe remaining starting materials were distilled away from the product which
filtrationwas further purified by filtration through a plug of silica-gel (methylene chloride)
concentrationconcentrated

出典と根拠

ORDレコード: ord-59f4e1b0ad244a8395f1a021e11528f6
出典データセット: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07285545B2

反応ノート

読み込み中…

参加物