Hydrochloric Acid → HCID 178514724、化合物

HRID 1182059

反応式

HRID 1182059 の反応式
[Br:1][C:2]1[C:3]([OH:9])=[N:4][C:5](Cl)=[N:6][CH:7]=1.[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[N:15][CH:16]=1.Cl>CN(C=O)C>[Br:1][C:2]1[C:3]([OH:9])=[N:4][C:5]([NH:10][C:11]2[CH:12]=[CH:13][C:14]([S:17]([NH2:20])(=[O:19])=[O:18])=[N:15][CH:16]=2)=[N:6][CH:7]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 223138505-Aminopyridine-2-sulfonamideHCID 178517822HCID 178517822、化合物

生成物 1

HCID 178514724HCID 178514724、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

2.0 g (9.62 mmol) of 5-bromo-2-chloro-4-hydroxypyrimidine and 1.686 g (9.62 mmol) of 5-amino-pyridine-2-sulfonic acid amide are mixed in 50 ml of DMF (p.a.) with 2.88 ml of hydrochloric acid (4 molar in dioxane). It is stirred for 30 hours at 100° C., cooled and concentrated by evaporation. After being taken up in methanol, 1.505 g (45% of theory) of 5-(5-bromo-4-hydroxy-pyrimidin-2-ylamino)-pyridine-2-sulfonic acid amide is crystallized out, which is dried at 50° C. in a vacuum.

後処理

  1. temperaturecooled
  2. concentrationconcentrated by evaporation
  3. custom1.505 g (45% of theory) of 5-(5-bromo-4-hydroxy-pyrimidin-2-ylamino)-pyridine-2-sulfonic acid amide is crystallized out
  4. customwhich is dried at 50° C. in a vacuum

出典と根拠

ORDレコード
ord-39cc0872a6404d7a83f4585697892184
出典データセット
uspto-grants-2007_10
特許番号
US07288547B2

関連ノート

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