1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-cyclopropyl-2-methyl-2H-pyrazol-3-yl)-urea → 1-{(S)-3-[3-(4-fluoro-benzyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-cyclo-propyl-2-methyl-2H-pyrazol-3-yl)-urea

HRID 1182143ノート

反応式

HRID 1182143 の反応式
ClC1C=CC(O[CH:7]2[CH2:10][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]3[N:21]([CH3:28])[N:22]=[C:23]([CH:25]4[CH2:27][CH2:26]4)[CH:24]=3)=[O:18])[CH2:14][OH:15])[CH2:8]2)=CC=1.N[C@@H](CCN1CC([CH2:41][C:42]2[CH:47]=[CH:46][C:45]([F:48])=[CH:44][CH:43]=2)C1)CO>>[F:48][C:45]1[CH:46]=[CH:47][C:42]([CH2:41][CH:7]2[CH2:8][N:9]([CH2:11][CH2:12][C@H:13]([NH:16][C:17]([NH:19][C:20]3[N:21]([CH3:28])[N:22]=[C:23]([CH:25]4[CH2:26][CH2:27]4)[CH:24]=3)=[O:18])[CH2:14][OH:15])[CH2:10]2)=[CH:43][CH:44]=1

参加物

3

反応物 2

HCID 101272591-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-cyclopropyl-2-methyl-2H-pyrazol-3-yl)-ureaHCID 69410514(S)-2-amino-4-[3-(4-fluoro-benzyl)-azetidin-1-yl]-butan-1-ol

生成物 1

HCID 866008541-{(S)-3-[3-(4-fluoro-benzyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-cyclo-propyl-2-methyl-2H-pyrazol-3-yl)-urea

実験手順

This compound is prepared in a manner analogous to that used to prepare 1-{(S)-3-[3-(4-Chloro-phenoxy)-azetidin-1-yl]-1-hydroxymethyl-propyl}-3-(5-cyclopropyl-2-methyl-2H-pyrazol-3-yl)-urea in Example 83 except using (S)-2-amino-4-[3-(4-fluoro-benzyl)-azetidin-1-yl]-butan-1-ol in place of (S)-2-amino-4-[3-(4-chloro-phenoxy)-azetidin-1-yl]-butan-1-ol.

後処理

  1. customThis compound is prepared in a manner analogous to

出典と根拠

ORDレコード
ord-0604455b3ca741c3b1d1b4c1c80fa984
出典データセット
uspto-grants-2007_10
特許番号
US07288537B2

反応ノート

読み込み中…