1,2-Dichloroethane → 8-(1-Benzyl-4-(SR)-phenylpyrrolidin-3-(RS)-ylmethyl)-2-(4-bromobenzyl)-2,8-diaza-spiro[4.5]decan-1-one dihydrochloride

反応式

[Br:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[CH2:11][CH2:10][C:9]3([CH2:16][CH2:15][N:14]([CH2:17][CH:18]4[CH:22]([C:23]5[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH2:21][NH:20][CH2:19]4)[CH2:13][CH2:12]3)[C:8]2=[O:29])=[CH:4][CH:3]=1.[CH:32](=O)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Cl:53]CCCl>>[ClH:53].[ClH:53].[CH2:32]([N:20]1[CH2:21][CH:22]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:18]([CH2:17][N:14]2[CH2:13][CH2:12][C:9]3([C:8](=[O:29])[N:7]([CH2:6][C:5]4[CH:4]=[CH:3][C:2]([Br:1])=[CH:31][CH:30]=4)[CH2:11][CH2:10]3)[CH2:16][CH2:15]2)[CH2:19]1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1