Methanol → Methyl 2-(3,5-difluorophenyl)-2-hydroxyacetate
反応式
S(=O)(=O)(O)O.[F:6][C:7]1[CH:8]=[C:9]([CH:15]=[C:16]([F:18])[CH:17]=1)[CH:10]([OH:14])[C:11]([OH:13])=[O:12].[CH3:19]O>>[F:6][C:7]1[CH:8]=[C:9]([CH:15]=[C:16]([F:18])[CH:17]=1)[CH:10]([OH:14])[C:11]([O:13][CH3:19])=[O:12]参加物
4
実験手順
2 ml of sulfuric acid at 95% by mass are added to 2 g of 3,5-difluoromandelic acid in solution in 25 ml of methanol, and the mixture is kept under reflux for 6 hours. The medium is concentrated, the residue is taken up in ethyl acetate and washed with a sodium hydroxide solution (0.1 N). The organic phase is dried over anhydrous sodium sulfate and 2 g of oil are obtained.
後処理
- temperatureunder reflux for 6 hours
- concentrationThe medium is concentrated
- washwashed with a sodium hydroxide solution (0.1 N)
- dry with materialThe organic phase is dried over anhydrous sodium sulfate and 2 g of oil
- customare obtained
出典と根拠
- ORDレコード
- ord-1f7aa94e215343c5bad3a6062a7dcddc
- 出典データセット
- uspto-grants-2007_10
- 特許番号
- US07288659B2
反応ノート
読み込み中…