Potassium Carbonate → 2-(5-Bromo-2-cyano-3-fluorophenylamino)acetamide
反応式
[Br:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[C:4]([F:11])[CH:3]=1.Cl.[NH2:13][CH2:14][C:15]([NH2:17])=[O:16].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[C:4]([F:11])[C:5]([C:6]#[N:7])=[C:8]([NH:13][CH2:14][C:15]([NH2:17])=[O:16])[CH:9]=1参加物
5
反応条件
- 温度
- 70 °C
実験手順
12.6 (58.3 mmol) 4-bromo-2,6-difluorobenzonitrile, 6.8 g (61.5 mmol) glycinamide hydrochloride and 16.1 g (116.5 mmol) K2CO3 were suspended in 50 ml DMF and heated at 70° C. for 18 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 13.3 g (84%) 2-(5-bromo-2-cyano-3-fluorophenylamino)acetamide was obtained. ESI-MS [m/z]: 272, 274 [M+H]+
後処理
- temperatureHaving cooled down to room temperature
- concentrationthe solvent was concentrated
- additionwater was added
- washwashed with water
出典と根拠
- ORDレコード
- ord-e1cb3601729e42329260fca4e330e510
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664233B2
反応ノート
読み込み中…