Potassium Carbonate → HCID 66864166、化合物
反応式
[Br:1][C:2]1[C:3](F)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].Cl.[NH2:12][CH2:13][C:14]([NH2:16])=[O:15].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[C:3]=1[NH:12][CH2:13][C:14]([NH2:16])=[O:15]参加物
5
反応条件
- 温度
- 100 °C
実験手順
10.0 g (50.0 mmol) 3-bromo-2-fluorobenzonitrile, 11.1 g (100.0 mmol) glycinamide hydrochloride and 17.3 g (125 mmol) K2CO3 were suspended in 90 ml DMSO and heated at 100° C. for 4 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 10.8 g (85%) 2-(2-bromo-6-cyano-phenylamino)acetamide was obtained. ESI-MS [m/z]: 254, 256 [M+H]+
後処理
- temperatureHaving cooled down to room temperature
- concentrationthe solvent was concentrated
- additionwater was added
- washwashed with water
出典と根拠
- ORDレコード
- ord-50fb28455ce242dc825b93781f50cab8
- 出典データセット
- uspto-grants-2014_03
- 特許番号
- US08664233B2
反応ノート
読み込み中…