[Cl:1][C:2]1[C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[N:3]=1.[CH3:19][Si](C=[N+]=[N-])(C)C.C(O)(=O)C>CO.C1(C)C=CC=CC=1.CCCCCC>[Cl:1][C:2]1[C:7]([C:8]([O:10][CH3:19])=[O:9])=[CH:6][CH:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[O:17][CH3:18])[N:3]=1
500 mg (1.90 mmol) of 2-chloro-6-(2-methoxyphenyl)pyridine-3-carboxylic acid were initially charged in a mixture of 20 ml of methanol and 8 ml of toluene and admixed with 8 ml (16 mmol) of a 2 molar solution of trimethylsilyldiazomethane in hexane. The mixture was stirred at RT for 15 h and then 1 ml of acetic acid was added. The solvent was removed fully under reduced pressure, and the resulting solid was used without further purification. 502 mg (87% of theory) of the product were obtained.
読み込み中…
