2-Chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile → HCID 44625508、化合物

HRID 1183014ノート

反応式

HRID 1183014 の反応式
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=[C:4]([C:14]2[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=2)[N:3]=1.Cl.[NH:22]1[CH2:27][CH2:26][CH2:25][CH:24]([NH:28][C:29]2[N:34]=[CH:33][C:32]([C:35]#[N:36])=[CH:31][CH:30]=2)[CH2:23]1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:4]2[N:3]=[C:2]([N:22]3[CH2:27][CH2:26][CH2:25][CH:24]([NH:28][C:29]4[CH:30]=[CH:31][C:32]([C:35]#[N:36])=[CH:33][N:34]=4)[CH2:23]3)[C:7]([C:8]#[N:9])=[C:6]([C:10]([F:13])([F:12])[F:11])[CH:5]=2)=[CH:15][CH:16]=1

参加物

3

反応物 2

HCID 14771902-Chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrileHCID 670603386-(Piperidin-3-ylamino)nicotinonitrile hydrochloride

生成物 1

HCID 44625508HCID 44625508、化合物

実験手順

Analogously to the preparation of Example 20, 60 mg (0.19 mmol) of 2-chloro-6-(4-chlorophenyl)-4-(trifluoromethyl)pyridine-3-carbonitrile and 56 mg (0.23 mmol) of 6-(piperidin-3-ylamino)pyridine-3-carbonitrile hydrochloride (Example 10A) were used to obtain, after separation by means of preparative HPLC (method 13), 46 mg (50% of theory) of the product in solid form.

後処理

  1. customto obtain
  2. customafter separation by means of preparative HPLC (method 13), 46 mg (50% of theory) of the product in solid form

出典と根拠

ORDレコード
ord-49383c08d9e248bfb949e59587afbb24
出典データセット
uspto-grants-2014_03
特許番号
US08664246B2

反応ノート

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